SFTPA1

Across TCGA patient cohorts, SFTPA1 mutation is significantly associated with the RNA expression of many other genes, with 806 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFTPA1-associated genes across cancer lineages are IL21, NECTIN4, and RNU6-1279P. Each is linked with SFTPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFTPA1-to-partner and partner-to-SFTPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL21 grouped by SFTPA1-low versus SFTPA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFTPA1→partner) and Y-score (partner→SFTPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IL21 →	+0.129	+2.219	.002	.003	3	2
UCEC	NECTIN4 →	-1.210	-2.689	<.001	.006	3	2
LUAD	RNU6-1279P →	+0.517	+4.628	.002	.004	3	2
LUAD	ELF2P3 →	+0.261	+4.631	<.001	.008	3	2
BLCA	GNG10P1 →	+0.260	+5.038	<.001	.009	3	2
LUSC	RNA5SP161 →	+0.271	+4.059	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 806 associations by consensus.

IL21 by SFTPA1 expression — UCEC

Explore this box plot interactively →