SFTPA1

Across TCGA pan-cancer cohorts, SFTPA1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SFTPA1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SFTPA1 RNA is repressed in tumor relative to normal tissue. In most cancer types SFTPA1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and THCA are the cancer types where SFTPA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SFTPA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	−6.021	<.001	9	view →
LUSC	Male	II,III,IV	−8.512	<.001	8	view →
THCA	All	All	+1.602	<.001	7	view →
COAD	All	II,III,IV	−0.165	.003	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SFTPA1–LUAD

Open the LUAD breakdown →