Across TCGA patient cohorts, SF3B3 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,363 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SF3B3-associated proteins across cancer lineages are DHX38, USP10, and CFDP1. Each is linked with SF3B3 in more than 7 cancer types. Because this analysis shows association rather than direction, both SF3B3-to-partner and partner-to-SF3B3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B3→partner) and Y-score (partner→SF3B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DHX38 →	+0.307	+0.501	<.001	<.001	3	8
LSCC	USP10 →	+0.300	+0.597	<.001	<.001	3	7
CCRCC	CFDP1 →	+0.346	+0.353	<.001	<.001	3	7
BRCA	CIAPIN1 →	+0.306	+0.644	<.001	<.001	3	7
LSCC	GMPS →	+0.480	+0.411	<.001	<.001	3	7
LSCC	CELF1 →	+0.302	+0.594	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,363 associations by consensus.

Exploration

SF3B3 survival (RNA) · tumor vs normal (RNA) · all SF3B3 data types