Across TCGA pan-cancer cohorts, SF3B3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SF3B3 data layer compared with 11 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher SF3B3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SF3B3 expression acts as an unfavorable survival marker, although some lineages such as SCLC and KIRC show a favorable association.

SCLC, MESO, and KIRC are the cancer types where SF3B3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Quartile	II,III,IV	0.727	0.267	<.001	69	view →
MESO	DFS	Median	IV	0.189	0.521	.002	55	view →
KIRC	DFS	Median	All	0.767	0.481	<.001	48	view →
ACC	OS	Median	All	0.770	0.967	<.001	37	view →
UVM	DFS	Quartile	All	0.876	0.360	.002	34	view →
LIHC	DFS	Median	All	0.468	0.615	<.001	29	view →
BLCA	DFS	Quartile	All	0.407	0.540	.015	28	view →
LUSC	DFS	Quartile	III,IV	0.227	0.935	<.001	27	view →
PAAD	DFS	Quartile	All	0.315	0.609	.007	25	view →
KIRP	DFS	Tertile	IV	0.102	0.492	.021	19	view →
CESC	DFS	Median	III,IV	0.485	0.790	.010	18	view →
HNSC	OS	Median	II,III,IV	0.703	0.784	.008	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

Exploration

Same gene, other analysis: SF3B3 tumor-vs-normal RNA expression · all SF3B3 data types