Across TCGA patient cohorts, SF3B3 mutation is significantly associated with the RNA expression of many other genes, with 5,482 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SF3B3-associated genes across cancer lineages are RNU1-75P, RNU6-1176P, and RNA5SP198. Each is linked with SF3B3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SF3B3-to-partner and partner-to-SF3B3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B3→partner) and Y-score (partner→SF3B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU1-75P →	+0.853	+3.411	<.001	.009	3	3
CESC	RNU6-1176P →	+0.353	+3.376	<.001	.007	3	3
CESC	RNA5SP198 →	+0.315	+4.144	<.001	.009	3	3
LUSC	RNU6-1256P →	+0.291	+3.372	<.001	.002	3	3
CESC	MRPS31P1 →	+0.165	+4.837	<.001	.003	3	3
SKCM	TRABD →	+0.453	+2.328	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,482 associations by consensus.

Exploration

SF3B3 survival (RNA) · tumor vs normal (RNA) · all SF3B3 data types