SF3B1

Across TCGA patient cohorts, SF3B1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,371 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SF3B1-associated genes across cancer lineages are NCAPH, F13A1, and SGO1. Each is linked with SF3B1 in more than 8 cancer types. Because this analysis shows association rather than direction, both SF3B1-to-partner and partner-to-SF3B1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SF3B1 versus NCAPH in UCEC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B1→partner) and Y-score (partner→SF3B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPH →	+0.983	+0.177	<.001	<.001	3	8
BRCA	F13A1 →	-1.378	-0.193	<.001	<.001	3	8
UCEC	SGO1 →	+0.893	+0.134	<.001	.001	3	8
UCEC	NUF2 →	+1.266	+0.175	<.001	<.001	3	8
COAD	FLI1 →	-0.719	-0.159	<.001	<.001	3	8
UCEC	TRAIP →	+1.113	+0.146	<.001	<.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,371 associations by consensus.

SF3B1 vs NCAPH — UCEC

Explore this scatter interactively →