SF3B1

Across TCGA pan-cancer cohorts, SF3B1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SF3B1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SF3B1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SF3B1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LIHC, and KICH are the cancer types where SF3B1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SF3B1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.666	<.001	10	view →
LIHC	All	II,III,IV	+0.907	<.001	8	view →
KICH	Female	II,III,IV	−1.585	<.001	7	view →
COAD	Male	All	+0.482	<.001	7	view →
STAD	All	II,III,IV	+0.826	.001	6	view →
BLCA	Female	III,IV	+0.580	.001	6	view →
CHOL	Male	All	+1.756	<.001	5	view →
LUAD	All	All	+0.272	.001	4	view →
READ	All	All	+0.435	.001	3	view →
ESCA	Female	All	+0.823	.006	2	view →
KIRP	All	IV	+0.727	.013	2	view →
LUSC	All	All	+0.347	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SF3B1–HNSC

Open the HNSC breakdown →