SF3B1

Across TCGA patient cohorts, SF3B1 mutation is significantly associated with the RNA expression of many other genes, with 6,521 significant associations in total. UVM shows the largest number of these associations.

The most reproducible SF3B1-associated genes across cancer lineages are MIR455, AKAP8L, and IGSF22. Each is linked with SF3B1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SF3B1-to-partner and partner-to-SF3B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR455 grouped by SF3B1-low versus SF3B1-high in UVM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B1→partner) and Y-score (partner→SF3B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	MIR455 →	+0.549	+2.629	<.001	<.001	3	6
BRCA	AKAP8L →	-0.451	-3.796	.002	<.001	3	4
UCEC	IGSF22 →	-0.239	-1.496	.001	.002	3	4
UVM	IKBKE →	-0.710	-3.584	<.001	<.001	3	4
PRAD	MRPL32P1 →	+0.164	+6.206	<.001	.001	3	3
PRAD	LINC02558 →	+0.232	+5.352	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,521 associations by consensus.

MIR455 by SF3B1 expression — UVM

Explore this box plot interactively →