SF3B1

Across TCGA cell cohorts, SF3B1 mutation is significantly associated with the RNA expression of many other genes, with 394 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SF3B1-associated genes across cancer lineages are CT45A8, ACP4, and DEFA6. Each is linked with SF3B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3B1-to-partner and partner-to-SF3B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CT45A8 grouped by SF3B1-low versus SF3B1-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B1→partner) and Y-score (partner→SF3B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CT45A8 →	+0.213	+3.688	.002	.007	3	2
PANCREAS	ACP4 →	+0.017	+3.917	.003	.004	3	2
PANCREAS	DEFA6 →	+0.056	+3.201	.005	.008	3	2
PANCREAS	PRSS45P →	+0.304	+3.869	<.001	.002	3	2
BLOOD_Leukemia	TNFSF8 →	+1.346	+3.765	.002	.001	3	2
BREAST	FAM47B →	+0.010	+4.196	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 394 associations by consensus.

CT45A8 by SF3B1 expression — BONE

Explore this box plot interactively →