SERPINE1

Across TCGA patient cohorts, SERPINE1 mutation is significantly associated with the RNA expression of many other genes, with 1,717 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINE1-associated genes across cancer lineages are RN7SL837P, RNA5SP197, and KRT18P12. Each is linked with SERPINE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERPINE1-to-partner and partner-to-SERPINE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL837P grouped by SERPINE1-low versus SERPINE1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINE1→partner) and Y-score (partner→SERPINE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL837P →	+0.101	+4.671	<.001	.004	3	3
HNSC	RNA5SP197 →	+0.553	+3.787	<.001	.002	3	2
HNSC	KRT18P12 →	+0.068	+3.385	<.001	.007	3	2
CESC	TPT1P11 →	+0.147	+5.418	<.001	.005	3	2
CESC	RPL17P49 →	+0.143	+6.342	<.001	.001	3	2
UCEC	MTA2 →	+0.418	+3.502	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,717 associations by consensus.

RN7SL837P by SERPINE1 expression — SKCM

Explore this box plot interactively →