SERPINE1

Across TCGA pan-cancer cohorts, SERPINE1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SERPINE1 data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SERPINE1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SERPINE1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and DLBC show a favorable association.

HNSC, STAD, and KIRP are the cancer types where SERPINE1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.535	0.672	<.001	138	view →
STAD	OS	Median	All	0.305	0.541	<.001	104	view →
KIRP	DFS	Median	II,III,IV	0.521	0.841	<.001	103	view →
MESO	OS	Median	All	0.407	0.680	<.001	96	view →
LUSC	OS	Median	All	0.597	0.747	<.001	83	view →
UVM	OS	Tertile	All	0.410	0.783	.003	56	view →
LGG	DFS	Median	All	0.638	0.836	<.001	54	view →
LUAD	DFS	Tertile	All	0.719	0.840	<.001	44	view →
SKCM	OS	Median	II,III,IV	0.405	0.175	<.001	40	view →
BLCA	OS	Quartile	All	0.504	0.664	.010	40	view →
COAD	DFS	Tertile	All	0.601	0.766	.001	39	view →
OV	DFS	Tertile	All	0.470	0.598	.002	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SERPINE1–HNSC (DFS)

Open the HNSC breakdown →