SERPINE1

Across TCGA pan-cancer cohorts, SERPINE1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SERPINE1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SERPINE1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SERPINE1 is over-expressed in tumor, although a few such as KICH and LIHC show the opposite, repressed pattern.

HNSC, COAD, and STAD are the cancer types where SERPINE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SERPINE1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+4.902	<.001	12	view →
COAD	Male	II,III,IV	+2.247	<.001	11	view →
STAD	All	III,IV	+2.858	<.001	10	view →
KIRC	Male	All	+2.292	<.001	9	view →
BRCA	Female	All	+1.375	<.001	6	view →
KICH	Female	All	−3.238	<.001	5	view →
LIHC	Female	All	−2.150	<.001	5	view →
THCA	Male	All	+1.405	.001	5	view →
READ	All	All	+2.563	.014	4	view →
KIRP	All	All	−1.041	.020	2	view →
ESCA	All	All	+2.753	.012	1	view →
BLCA	Male	IV	+2.112	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SERPINE1–HNSC

Open the HNSC breakdown →