SERPINE1

Across TCGA cell cohorts, SERPINE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,018 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SERPINE1-associated GO terms across cancer lineages are Dentinogenesis, Regulation of smooth muscle cell-matrix adhesion, and Fibrinolysis. Each is linked with SERPINE1 in more than 18 cancer types. Because this analysis shows association rather than direction, both SERPINE1-to-partner and partner-to-SERPINE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dentinogenesis grouped by SERPINE1-low versus SERPINE1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINE1→partner) and Y-score (partner→SERPINE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Dentinogenesis →	+2.397	+5.039	<.001	<.001	3	19
LARGE_INTESTINE	Regulation of smooth muscle cell-matrix adhesion →	+1.511	+3.358	<.001	<.001	3	18
BONE	Fibrinolysis →	+2.312	+5.743	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Regulation of hemostasis →	+0.256	+6.618	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Regulation of blood coagulation →	+0.256	+6.618	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Wound healing →	+0.152	+7.088	.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,018 associations by consensus.

Dentinogenesis by SERPINE1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →