SERPINE1

Across TCGA cell cohorts, SERPINE1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SERPINE1-associated genes across cancer lineages are GPR101, PRAMEF9, and C16orf90. Each is linked with SERPINE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINE1-to-partner and partner-to-SERPINE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR101 grouped by SERPINE1-low versus SERPINE1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINE1→partner) and Y-score (partner→SERPINE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GPR101 →	+0.015	+4.087	<.001	.009	3	1
URINARY_TRACT	PRAMEF9 →	+0.010	+4.087	<.001	.009	3	1
URINARY_TRACT	C16orf90 →	+0.017	+4.087	<.001	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	S100G →	+2.043	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GPR101 by SERPINE1 expression — URINARY_TRACT

Explore this box plot interactively →