Across TCGA cell cohorts, SERPINB4 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SERPINB4-associated genes across cancer lineages are ACSM2A, SMIM9, and HAO1. Each is linked with SERPINB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB4-to-partner and partner-to-SERPINB4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB4→partner) and Y-score (partner→SERPINB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ACSM2A →	+0.027	+3.523	<.001	.008	3	2
LUNG_SCLC	SMIM9 →	+0.061	+3.817	<.001	.004	3	2
LUNG_SCLC	HAO1 →	+0.018	+4.070	.002	.003	3	1
LUNG_SCLC	F9 →	+0.022	+4.058	<.001	.007	3	1
LUNG_SCLC	DEFB125 →	+0.052	+4.058	<.001	.007	3	1
SKIN	AVPR1B →	+0.013	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

SERPINB4 survival (RNA) · tumor vs normal (RNA) · all SERPINB4 data types