SERF1A

Across TCGA patient cohorts, SERF1A RNA expression is significantly associated with the go_rna of many other GO terms, with 6,027 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SERF1A-associated GO terms across cancer lineages are Rescue of stalled ribosome, Transport along microtubule, and Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Each is linked with SERF1A in more than 17 cancer types. Because this analysis shows association rather than direction, both SERF1A-to-partner and partner-to-SERF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rescue of stalled ribosome grouped by SERF1A-low versus SERF1A-high in ACC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERF1A→partner) and Y-score (partner→SERF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	Rescue of stalled ribosome →	+0.039	+0.161	<.001	<.001	3	17
ESCA	Transport along microtubule →	+0.032	+0.085	<.001	.003	2	17
ESCA	Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.042	+0.096	<.001	<.001	2	17
LAML	Maturation of SSU-rRNA →	+0.054	+0.157	<.001	<.001	2	17
ESCA	RNA 3'-end processing →	+0.039	+0.077	.001	.004	1	18
KICH	Subtelomeric heterochromatin formation →	+0.052	+0.086	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,027 associations by consensus.

Rescue of stalled ribosome by SERF1A expression — ACC

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