SERF1A

Across TCGA pan-cancer cohorts, SERF1A RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SERF1A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SERF1A RNA is repressed in tumor relative to normal tissue. In most cancer types SERF1A is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, LIHC, and LUAD are the cancer types where SERF1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SERF1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.175	<.001	5	view →
LIHC	All	All	+0.036	<.001	3	view →
LUAD	All	IV	+0.080	.015	2	view →
CHOL	All	All	+0.135	.023	1	view →
COAD	All	All	−0.067	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SERF1A–KICH

Open the KICH breakdown →