SERF1A

Across TCGA pan-cancer cohorts, SERF1A RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SERF1A data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SERF1A RNA is associated with better overall survival. In most high-consensus cancer types, elevated SERF1A expression acts as an unfavorable survival marker, although some lineages such as LUSC and DLBC show a favorable association.

LUSC, KICH, and LIHC are the cancer types where SERF1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.502	0.324	<.001	69	view →
KICH	OS	Median	III,IV	0.567	0.928	.008	39	view →
LIHC	OS	Median	III,IV	0.328	0.749	<.001	38	view →
DLBC	DFS	Tertile	III,IV	1.000	0.157	.003	30	view →
THCA	OS	Tertile	II,III,IV	0.961	0.995	.010	26	view →
BRCA	OS	Tertile	IV	0.855	0.371	.008	24	view →
THYM	DFS	Median	All	0.766	0.976	.005	23	view →
UVM	DFS	Quartile	All	0.336	0.776	.005	18	view →
MESO	DFS	Median	III,IV	0.663	0.238	.005	18	view →
HNSC	DFS	Quartile	III,IV	0.319	0.727	.003	10	view →
KIRP	OS	Tertile	All	0.805	1.000	.004	10	view →
CHOL	DFS	Quartile	II,III,IV	0.697	0.219	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SERF1A–LUSC (OS)

Open the LUSC breakdown →