SERAC1

Across TCGA patient cohorts, SERAC1 protein abundance is significantly associated with the RNA expression of many other genes, with 5,988 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SERAC1-associated genes across cancer lineages are SMC4, CENPF, and KIF14. Each is linked with SERAC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SERAC1-to-partner and partner-to-SERAC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SERAC1 versus SMC4 in BRCA, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERAC1→partner) and Y-score (partner→SERAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMC4 →	-1.000	-0.428	<.001	.005	3	5
HNSC	CENPF →	-1.263	-0.305	<.001	<.001	3	5
BRCA	KIF14 →	-1.196	-0.509	<.001	<.001	3	5
HNSC	CCNB1 →	-0.825	-0.327	<.001	<.001	3	5
BRCA	KIF11 →	-1.063	-0.478	<.001	<.001	3	5
HNSC	DNA2 →	-0.877	-0.300	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,988 associations by consensus.

SERAC1 vs SMC4 — BRCA

Explore this scatter interactively →