SERAC1

Across TCGA pan-cancer cohorts, SERAC1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SERAC1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SERAC1 RNA is repressed in tumor relative to normal tissue. In most cancer types SERAC1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and LIHC are the cancer types where SERAC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SERAC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.472	<.001	11	view →
KIRC	Male	III,IV	−0.695	<.001	9	view →
LIHC	Female	All	+0.509	<.001	7	view →
CHOL	All	All	+1.686	<.001	3	view →
THCA	All	II,III,IV	−0.333	.016	3	view →
BLCA	All	All	+0.320	.028	3	view →
UCEC	All	All	+0.425	.048	2	view →
LUAD	All	IV	+0.395	.033	2	view →
LUAD	Female	III,IV	−0.376	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 8 lineages.

SERAC1–KICH

Open the KICH breakdown →