SERAC1

Across TCGA patient cohorts, SERAC1 mutation is significantly associated with the RNA expression of many other genes, with 2,827 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERAC1-associated genes across cancer lineages are COASY, RNA5SP502, and RNU6-336P. Each is linked with SERAC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERAC1-to-partner and partner-to-SERAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COASY grouped by SERAC1-low versus SERAC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERAC1→partner) and Y-score (partner→SERAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COASY →	+0.467	+2.021	<.001	.001	3	2
SKCM	RNA5SP502 →	+0.274	+3.594	<.001	.003	3	2
SKCM	RNU6-336P →	+0.232	+3.594	<.001	.003	3	2
UCEC	L3MBTL2 →	+0.293	+2.848	.007	.001	3	2
UCEC	TAF1C →	+0.397	+2.392	.001	<.001	3	2
UCEC	RRBP1 →	+0.417	+2.534	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,827 associations by consensus.

COASY by SERAC1 expression — UCEC

Explore this box plot interactively →