SEPTIN7

Across TCGA cell cohorts, SEPTIN7 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,044 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEPTIN7-associated GO terms across cancer lineages are Negative regulation of metaphase/anaphase transition of cell cycle, Negative regulation of chromosome separation, and Mitotic spindle assembly checkpoint signaling. Each is linked with SEPTIN7 in more than 17 cancer types. Because this analysis shows association rather than direction, both SEPTIN7-to-partner and partner-to-SEPTIN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of metaphase/anaphase transition of cell cycle grouped by SEPTIN7-low versus SEPTIN7-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN7→partner) and Y-score (partner→SEPTIN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.145	+0.705	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome separation →	+0.145	+0.705	<.001	<.001	3	18
BREAST	Mitotic spindle assembly checkpoint signaling →	+0.160	+0.878	<.001	<.001	3	18
BREAST	Spindle assembly checkpoint signaling →	+0.160	+0.878	<.001	<.001	3	18
BREAST	Mitotic spindle checkpoint signaling →	+0.160	+0.878	<.001	<.001	3	18
BREAST	Negative regulation of mitotic sister chromatid separation →	+0.170	+0.880	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,044 associations by consensus.

Negative regulation of metaphase/anaphase transition of cell cycle by SEPTIN7 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →