SEPTIN7

Across TCGA cell cohorts, SEPTIN7 mutation is significantly associated with the mutation status of many other genes, with 969 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEPTIN7-associated genes across cancer lineages are DHX9, A1CF, and ABL2. Each is linked with SEPTIN7 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEPTIN7-to-partner and partner-to-SEPTIN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DHX9 grouped by SEPTIN7-low versus SEPTIN7-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN7→partner) and Y-score (partner→SEPTIN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DHX9 →	+4.429	+5.247	.005	.005	1	3
BLOOD_Lymphoma	A1CF →	+5.014	+5.584	.003	.003	1	3
SKIN	ABL2 →	+4.239	+5.053	.007	.007	1	2
SKIN	CDK1 →	+5.824	+5.824	.002	.002	1	2
BLOOD_Lymphoma	BARHL1 →	+5.014	+5.584	.003	.003	1	2
BLOOD_Lymphoma	SYMPK →	+4.429	+5.247	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 969 associations by consensus.

DHX9 by SEPTIN7 expression — BLOOD_Lymphoma

Explore this box plot interactively →