SEPTIN14

Across TCGA patient cohorts, SEPTIN14 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,300 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SEPTIN14-associated GO terms across cancer lineages are Regulation of DNA repair, Microtubule organizing center organization, and Regulation of microtubule-based process. Each is linked with SEPTIN14 in more than 15 cancer types. Because this analysis shows association rather than direction, both SEPTIN14-to-partner and partner-to-SEPTIN14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by SEPTIN14-low versus SEPTIN14-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN14→partner) and Y-score (partner→SEPTIN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of DNA repair →	+0.069	+0.360	<.001	<.001	3	16
STAD	Microtubule organizing center organization →	+0.065	+0.351	<.001	<.001	3	15
ESCA	Regulation of microtubule-based process →	+0.066	+0.330	<.001	.004	2	16
ESCA	Regulation of double-strand break repair via homologous recombination →	+0.080	+0.464	<.001	.001	2	15
STAD	Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.077	+0.279	<.001	<.001	3	14
ESCA	Telomere organization →	+0.075	+0.416	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,300 associations by consensus.

Regulation of DNA repair by SEPTIN14 expression — STAD

Explore this box plot interactively →