SEPTIN14

Across TCGA pan-cancer cohorts, SEPTIN14 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SEPTIN14 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher SEPTIN14 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEPTIN14 expression acts as an unfavorable survival marker, although some lineages such as PAAD and CHOL show a favorable association.

LGG, KIRC, and ACC are the cancer types where SEPTIN14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.665	0.791	<.001	38	view →
KIRC	DFS	Tertile	IV	0.202	0.562	.011	38	view →
ACC	OS	Quartile	All	0.237	0.663	<.001	30	view →
PAAD	OS	Tertile	II,III,IV	0.762	0.366	.024	21	view →
CHOL	DFS	Tertile	II,III,IV	0.754	0.225	.026	21	view →
UCS	OS	Tertile	IV	0.233	0.679	.024	12	view →
SCLC	OS	Tertile	All	0.507	0.896	.024	12	view →
KICH	OS	Tertile	II,III,IV	0.746	0.956	.038	11	view →
LUSC	DFS	Tertile	III,IV	0.245	0.727	.014	10	view →
BLCA	DFS	Quartile	All	0.468	0.621	.008	9	view →
READ	OS	Median	III,IV	0.664	0.280	.026	6	view →
BRCA	OS	Tertile	III,IV	0.354	0.601	.028	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SEPTIN14–LGG (DFS)

Open the LGG breakdown →