SEPTIN14

Across TCGA pan-cancer cohorts, SEPTIN14 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SEPTIN14’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SEPTIN14 RNA is repressed in tumor relative to normal tissue. In most cancer types SEPTIN14 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where SEPTIN14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEPTIN14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.024	.001	6	view →
HNSC	All	All	+0.023	.003	6	view →
LIHC	Female	All	+0.022	.034	2	view →
LUSC	All	II,III,IV	+0.012	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SEPTIN14–THCA

Open the THCA breakdown →