SEPTIN14

Across TCGA patient cohorts, SEPTIN14 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN14-associated genes across cancer lineages are Notch1, Annexin-1, and TFRC. Each is linked with SEPTIN14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN14-to-partner and partner-to-SEPTIN14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SEPTIN14-low versus SEPTIN14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN14→partner) and Y-score (partner→SEPTIN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.130	+1.598	.005	.040	3	2
UCEC	Annexin-1 →	+0.770	+2.999	<.001	<.001	3	2
UCEC	TFRC →	+0.487	+2.584	.006	.010	3	2
UCEC	TIGAR →	+0.109	+1.901	.033	.001	3	2
UCEC	ATM →	-0.440	-2.571	.003	.010	3	2
UCEC	Caspase-8 →	-0.298	-2.201	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Notch1 by SEPTIN14 expression — UCEC

Explore this box plot interactively →