SEPTIN14

Across TCGA cell cohorts, SEPTIN14 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEPTIN14-associated genes across cancer lineages are C6orf118, L3MBTL4, and TPD52L3. Each is linked with SEPTIN14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN14-to-partner and partner-to-SEPTIN14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by SEPTIN14-low versus SEPTIN14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN14→partner) and Y-score (partner→SEPTIN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.092	+2.793	.001	.002	3	1
LARGE_INTESTINE	L3MBTL4 →	+0.820	+3.478	<.001	.002	3	1
LARGE_INTESTINE	TPD52L3 →	+0.027	+2.777	.002	.004	3	1
LARGE_INTESTINE	REG1B →	+1.519	+2.518	.005	.006	3	1
LARGE_INTESTINE	GPR171 →	+0.014	+3.009	<.001	.001	3	1
LARGE_INTESTINE	ENTHD1 →	+0.025	+2.969	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

C6orf118 by SEPTIN14 expression — LARGE_INTESTINE

Explore this box plot interactively →