SEPSECS-AS1

Across TCGA patient cohorts, SEPSECS-AS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,193 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SEPSECS-AS1-associated proteins across cancer lineages are DDAH2, ERO1A, and JUNB. Each is linked with SEPSECS-AS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SEPSECS-AS1-to-partner and partner-to-SEPSECS-AS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEPSECS-AS1 versus DDAH2 in HNSC, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPSECS-AS1→partner) and Y-score (partner→SEPSECS-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DDAH2 →	+0.368	+0.505	<.001	<.001	3	5
LSCC	ERO1A →	-0.529	-0.480	<.001	<.001	3	5
HNSC	JUNB →	-0.397	-0.687	<.001	<.001	3	5
OV	PSIP1 →	+0.553	+0.361	<.001	.006	3	4
GBM	RPL13A →	-0.336	-0.443	.002	.002	3	4
GBM	RPL14 →	-0.561	-0.495	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,193 associations by consensus.

SEPSECS-AS1 vs DDAH2 — HNSC

Explore this scatter interactively →