SEPSECS-AS1

Across TCGA pan-cancer cohorts, SEPSECS-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SEPSECS-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SEPSECS-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SEPSECS-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and UCS show a favorable association.

UVM, MESO, and LGG are the cancer types where SEPSECS-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	III,IV	0.368	0.909	<.001	104	view →
MESO	DFS	Tertile	IV	0.187	0.726	.001	45	view →
LGG	DFS	Tertile	All	0.667	0.809	<.001	39	view →
PAAD	DFS	Quartile	All	0.461	0.209	.004	34	view →
UCS	DFS	Tertile	II,III,IV	0.564	0.214	.009	26	view →
THYM	OS	Median	II,III,IV	0.955	0.690	.004	25	view →
KICH	OS	Quartile	II,III,IV	0.425	1.000	.002	19	view →
ESCA	OS	Median	All	0.466	1.000	.016	15	view →
ACC	DFS	Quartile	All	0.274	0.689	.008	13	view →
BRCA	DFS	Tertile	All	0.400	0.592	.006	10	view →
SKCM	DFS	Median	All	0.251	0.161	.004	9	view →
HNSC	OS	Quartile	IV	0.662	0.835	.023	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SEPSECS-AS1–UVM (OS)

Open the UVM breakdown →