SEPSECS-AS1

Across TCGA pan-cancer cohorts, SEPSECS-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SEPSECS-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SEPSECS-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SEPSECS-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LIHC are the cancer types where SEPSECS-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEPSECS-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.595	<.001	10	view →
KICH	Female	II,III,IV	−0.978	<.001	9	view →
LIHC	All	II,III,IV	+0.672	<.001	9	view →
LUSC	Male	All	−0.434	<.001	6	view →
LUAD	Female	II,III,IV	−0.360	.013	4	view →
CHOL	Male	All	+0.573	<.001	2	view →
STAD	All	II,III,IV	+0.326	.028	1	view →
COAD	Female	All	−0.322	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

SEPSECS-AS1–THCA

Open the THCA breakdown →