SENP3-EIF4A1

Across TCGA pan-cancer cohorts, SENP3-EIF4A1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SENP3-EIF4A1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SENP3-EIF4A1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SENP3-EIF4A1 expression acts as an unfavorable survival marker, although some lineages such as READ and KIRP show a favorable association.

KIRC, LIHC, and ACC are the cancer types where SENP3-EIF4A1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	II,III,IV	0.312	0.705	.002	74	view →
LIHC	OS	Tertile	All	0.429	0.626	<.001	73	view →
ACC	DFS	Median	All	0.414	0.703	<.001	67	view →
LGG	DFS	Tertile	All	0.667	0.815	<.001	34	view →
SKCM	DFS	Tertile	All	0.168	0.388	<.001	32	view →
OV	DFS	Quartile	III,IV	0.453	0.559	.003	22	view →
SARC	OS	Median	All	0.388	0.733	<.001	22	view →
CHOL	DFS	Tertile	II,III,IV	0.103	0.806	.006	19	view →
READ	OS	Quartile	II,III,IV	0.844	0.350	.017	17	view →
THCA	OS	Quartile	II,III,IV	0.778	1.000	.014	15	view →
MESO	OS	Median	All	0.457	0.635	.008	9	view →
KIRP	DFS	Quartile	All	0.922	0.580	.026	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SENP3-EIF4A1–KIRC (DFS)

Open the KIRC breakdown →