SENP3-EIF4A1

Across TCGA pan-cancer cohorts, SENP3-EIF4A1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SENP3-EIF4A1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SENP3-EIF4A1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SENP3-EIF4A1 is over-expressed in tumor, although a few such as BRCA and PAAD show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where SENP3-EIF4A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SENP3-EIF4A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.117	<.001	9	view →
KIRC	All	All	+0.033	<.001	8	view →
BLCA	All	III,IV	+0.209	.002	6	view →
UCEC	All	III,IV	+0.201	<.001	6	view →
COAD	All	II,III,IV	+0.140	<.001	6	view →
KIRP	Female	All	+0.058	.005	4	view →
LIHC	Female	II,III,IV	+0.024	.010	4	view →
READ	All	III,IV	+0.280	.042	2	view →
BRCA	All	IV	−0.155	.001	2	view →
CHOL	All	All	+0.112	.016	2	view →
PAAD	Male	All	−0.099	.024	2	view →
KICH	Female	All	−0.056	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SENP3-EIF4A1–HNSC

Open the HNSC breakdown →