SEMA7A

Across TCGA cell cohorts, SEMA7A mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEMA7A-associated genes across cancer lineages are CPXCR1, SSMEM1, and MMP26. Each is linked with SEMA7A in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA7A-to-partner and partner-to-SEMA7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPXCR1 grouped by SEMA7A-low versus SEMA7A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA7A→partner) and Y-score (partner→SEMA7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CPXCR1 →	+0.069	+3.456	<.001	<.001	3	2
LARGE_INTESTINE	SSMEM1 →	+0.023	+3.029	.001	.006	3	1
LARGE_INTESTINE	MMP26 →	+0.027	+3.217	.002	.006	3	1
LARGE_INTESTINE	KRT1 →	+0.406	+3.772	.003	.003	3	1
LARGE_INTESTINE	GPR171 →	+0.019	+3.103	<.001	.004	3	1
LARGE_INTESTINE	FAM205C →	+0.008	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

CPXCR1 by SEMA7A expression — BLOOD_Leukemia

Explore this box plot interactively →