SEMA7A

Across TCGA pan-cancer cohorts, SEMA7A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SEMA7A data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SEMA7A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEMA7A expression acts as an unfavorable survival marker, although some lineages such as UCEC and UCS show a favorable association.

KIRP, MESO, and ACC are the cancer types where SEMA7A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.510	0.823	<.001	118	view →
MESO	OS	Median	II,III,IV	0.260	0.526	<.001	108	view →
ACC	DFS	Median	All	0.208	0.712	<.001	93	view →
KIRC	OS	Median	All	0.753	0.865	<.001	91	view →
UCEC	DFS	Tertile	III,IV	0.856	0.689	.002	52	view →
UVM	DFS	Median	III,IV	0.417	0.937	.001	50	view →
LUSC	DFS	Median	II,III,IV	0.253	0.481	<.001	44	view →
PAAD	DFS	Median	All	0.232	0.504	.001	38	view →
THCA	DFS	Quartile	All	0.887	0.966	.007	32	view →
UCS	DFS	Median	III,IV	0.515	0.154	.006	32	view →
THYM	OS	Tertile	II,III,IV	0.955	0.582	.003	24	view →
BLCA	OS	Quartile	III,IV	0.307	0.507	.016	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SEMA7A–KIRP (DFS)

Open the KIRP breakdown →