SEMA4G

Across TCGA patient cohorts, SEMA4G mutation is significantly associated with the RNA expression of many other genes, with 3,500 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA4G-associated genes across cancer lineages are HNRNPA1P63, RN7SL354P, and PSMC3IP. Each is linked with SEMA4G in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA4G-to-partner and partner-to-SEMA4G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HNRNPA1P63 grouped by SEMA4G-low versus SEMA4G-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4G→partner) and Y-score (partner→SEMA4G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	HNRNPA1P63 →	+0.115	+3.767	<.001	.006	3	3
UCEC	RN7SL354P →	+0.238	+1.914	<.001	.005	3	3
UCEC	PSMC3IP →	+0.796	+4.180	<.001	<.001	3	3
SKCM	MIR4439 →	+0.128	+2.813	.002	.003	3	3
SKCM	LINC02672 →	+0.059	+2.858	<.001	.009	3	3
BLCA	RPL23AP94 →	+0.087	+4.147	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,500 associations by consensus.

HNRNPA1P63 by SEMA4G expression — PRAD

Explore this box plot interactively →