SEMA4G

Across TCGA pan-cancer cohorts, SEMA4G RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SEMA4G’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SEMA4G RNA is repressed in tumor relative to normal tissue. In most cancer types SEMA4G is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, KIRC, and COAD are the cancer types where SEMA4G tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA4G RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.689	<.001	10	view →
KIRC	All	All	+0.484	<.001	9	view →
COAD	Female	II,III,IV	−0.967	<.001	8	view →
STAD	All	II,III,IV	+1.708	<.001	6	view →
LIHC	All	All	+0.607	.002	5	view →
READ	All	All	−0.883	.020	4	view →
LUSC	Male	All	−0.626	<.001	4	view →
PAAD	All	All	+1.644	.022	2	view →
CHOL	Female	All	+1.516	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SEMA4G–KICH

Open the KICH breakdown →