SEMA4F

Across TCGA patient cohorts, SEMA4F mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA4F-associated genes across cancer lineages are PCNA, 14-3-3_beta, and eEF2. Each is linked with SEMA4F in more than 3 cancer types. Because this analysis shows association rather than direction, both SEMA4F-to-partner and partner-to-SEMA4F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SEMA4F-low versus SEMA4F-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4F→partner) and Y-score (partner→SEMA4F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.316	+3.087	<.001	<.001	3	4
UCEC	14-3-3_beta →	-0.098	-1.673	.004	.040	3	2
UCEC	eEF2 →	+0.309	+1.247	.011	.045	3	2
UCEC	ERK2 →	+0.184	+1.700	.005	.040	3	2
UCEC	GAPDH →	+0.361	+2.459	.048	.018	3	2
UCEC	Notch1 →	+0.181	+1.335	<.001	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PCNA by SEMA4F expression — UCEC

Explore this box plot interactively →