SEMA4F

Across TCGA pan-cancer cohorts, SEMA4F RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SEMA4F data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SEMA4F RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEMA4F expression acts as an unfavorable survival marker, although some lineages such as OV and ESCA show a favorable association.

KIRC, DLBC, and UCEC are the cancer types where SEMA4F RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	IV	0.232	0.653	<.001	60	view →
DLBC	DFS	Median	All	0.578	0.935	.001	53	view →
UCEC	DFS	Median	All	0.792	0.879	.001	52	view →
BLCA	DFS	Tertile	IV	0.319	0.676	.004	50	view →
MESO	DFS	Quartile	All	0.204	0.456	<.001	40	view →
LIHC	OS	Quartile	All	0.613	0.820	<.001	40	view →
KIRP	OS	Tertile	II,III,IV	0.226	0.885	.006	31	view →
CESC	DFS	Quartile	All	0.736	0.878	.002	28	view →
GBM	OS	Median	All	0.216	0.323	.008	24	view →
OV	OS	Median	IV	0.492	0.281	.009	22	view →
SARC	OS	Median	All	0.661	0.814	<.001	14	view →
ESCA	OS	Tertile	II,III,IV	0.848	0.621	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SEMA4F–KIRC (DFS)

Open the KIRC breakdown →