SEMA4F

Across TCGA pan-cancer cohorts, SEMA4F RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SEMA4F’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SEMA4F RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEMA4F is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where SEMA4F tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA4F RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.796	<.001	12	view →
BLCA	Female	III,IV	+1.460	<.001	9	view →
LIHC	Female	II,III,IV	+1.253	<.001	9	view →
KIRP	All	All	+0.700	<.001	8	view →
COAD	Male	All	+0.612	<.001	7	view →
STAD	Male	II,III,IV	+1.023	<.001	6	view →
LUSC	All	II,III,IV	+0.826	<.001	5	view →
KICH	All	All	−0.697	<.001	5	view →
READ	All	All	+0.579	.004	4	view →
CHOL	Female	All	+2.323	<.001	3	view →
ESCA	All	All	+1.107	<.001	3	view →
THCA	All	II,III,IV	+0.238	.016	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SEMA4F–HNSC

Open the HNSC breakdown →