SEMA4F

Across TCGA cell cohorts, SEMA4F mutation is significantly associated with the RNA expression of many other genes, with 904 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA4F-associated genes across cancer lineages are MS4A3, ECE2, and KSR2. Each is linked with SEMA4F in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA4F-to-partner and partner-to-SEMA4F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A3 grouped by SEMA4F-low versus SEMA4F-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4F→partner) and Y-score (partner→SEMA4F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MS4A3 →	+0.065	+3.485	.003	.004	3	2
LARGE_INTESTINE	ECE2 →	+0.164	+2.054	.008	.008	3	2
LARGE_INTESTINE	KSR2 →	+0.447	+3.502	.001	.001	3	2
KIDNEY	NPVF →	+0.020	+5.000	<.001	.005	3	1
KIDNEY	GLYATL3 →	+0.043	+5.000	<.001	.005	3	1
KIDNEY	KLF18 →	+0.006	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 904 associations by consensus.

MS4A3 by SEMA4F expression — BLOOD_Lymphoma

Explore this box plot interactively →