SEMA4C

Across TCGA cell cohorts, SEMA4C mutation is significantly associated with the RNA expression of many other genes, with 737 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA4C-associated genes across cancer lineages are FOXE3, NPFFR1, and KLK15. Each is linked with SEMA4C in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA4C-to-partner and partner-to-SEMA4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXE3 grouped by SEMA4C-low versus SEMA4C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4C→partner) and Y-score (partner→SEMA4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FOXE3 →	+0.085	+3.237	.004	.008	3	2
BLOOD_Leukemia	NPFFR1 →	+0.010	+3.359	.001	.002	3	1
BLOOD_Leukemia	KLK15 →	+0.375	+3.091	<.001	.006	3	1
BLOOD_Leukemia	DEFB108B →	+0.090	+3.269	<.001	.007	3	1
BLOOD_Leukemia	KPNA7 →	+0.318	+3.474	<.001	.007	3	1
LUNG_SCLC	DUSP21 →	+0.042	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 737 associations by consensus.

FOXE3 by SEMA4C expression — LARGE_INTESTINE

Explore this box plot interactively →