SEMA4C

Across TCGA pan-cancer cohorts, SEMA4C RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SEMA4C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SEMA4C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEMA4C is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KIRC, THCA, and HNSC are the cancer types where SEMA4C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA4C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.038	<.001	11	view →
THCA	Male	All	+1.035	<.001	11	view →
HNSC	All	III,IV	+0.923	<.001	10	view →
KICH	Female	III,IV	−2.153	<.001	8	view →
LUAD	Male	II,III,IV	+0.986	<.001	8	view →
BLCA	All	IV	−0.891	.001	6	view →
LIHC	Female	All	+0.598	.003	6	view →
CHOL	Male	All	+1.805	<.001	5	view →
LUSC	All	II,III,IV	+0.920	<.001	5	view →
COAD	Female	All	+1.140	<.001	4	view →
UCEC	All	All	−0.634	<.001	4	view →
BRCA	All	III,IV	+0.469	.023	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SEMA4C–KIRC

Open the KIRC breakdown →