SEMA3F

Across TCGA patient cohorts, SEMA3F mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA3F-associated genes across cancer lineages are c-Kit, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with SEMA3F in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA3F-to-partner and partner-to-SEMA3F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by SEMA3F-low versus SEMA3F-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3F→partner) and Y-score (partner→SEMA3F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	c-Kit →	-0.701	-3.459	.011	.005	3	3
UCEC	Caspase-7-cleavedD198 →	+1.079	+3.827	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.268	+2.489	.011	.010	3	3
SKCM	p27 →	+0.187	+1.700	.014	.043	3	3
UCEC	PRDX1 →	+0.164	+2.584	.042	.010	3	2
UCEC	Annexin-1 →	+0.604	+3.479	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

c-Kit by SEMA3F expression — SKCM

Explore this box plot interactively →