SEMA3F

Across TCGA pan-cancer cohorts, SEMA3F RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SEMA3F data layer compared with 10 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SEMA3F RNA is associated with better overall survival. In most high-consensus cancer types, elevated SEMA3F expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, UVM, and ACC are the cancer types where SEMA3F RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.717	0.537	<.001	113	view →
UVM	DFS	Tertile	All	0.350	0.806	<.001	103	view →
ACC	DFS	Median	All	0.274	0.643	<.001	83	view →
LIHC	DFS	Median	All	0.467	0.612	<.001	44	view →
COAD	DFS	Tertile	II,III,IV	0.733	0.911	.003	44	view →
BRCA	OS	Tertile	III,IV	0.972	0.874	.004	39	view →
BLCA	DFS	Quartile	II,III,IV	0.594	0.449	.005	38	view →
THCA	DFS	Quartile	All	0.926	0.276	.001	31	view →
LGG	OS	Median	All	0.853	0.937	<.001	28	view →
KIRP	OS	Median	II,III,IV	0.631	0.820	.012	21	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	15	view →
LUAD	DFS	Quartile	IV	0.618	0.941	.013	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SEMA3F–KIRC (OS)

Open the KIRC breakdown →