SEMA3F

Across TCGA pan-cancer cohorts, SEMA3F RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SEMA3F’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SEMA3F RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEMA3F is over-expressed in tumor, although a few such as KIRP and LUAD show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where SEMA3F tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA3F RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.506	<.001	12	view →
COAD	Male	IV	+2.316	<.001	10	view →
LIHC	Female	II,III,IV	+1.942	<.001	9	view →
THCA	Female	II,III,IV	+1.155	<.001	8	view →
BRCA	All	III,IV	+1.113	<.001	6	view →
LUSC	All	All	+1.110	<.001	5	view →
READ	All	All	+1.047	<.001	5	view →
CHOL	All	All	+1.845	<.001	3	view →
KIRP	All	All	−0.801	.002	2	view →
KICH	All	All	+0.495	.022	2	view →
LUAD	Female	All	−0.493	.006	2	view →
PRAD	All	All	−0.304	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SEMA3F–KIRC

Open the KIRC breakdown →