SEMA3F

Across TCGA cell cohorts, SEMA3F mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SEMA3F-associated genes across cancer lineages are CCDC185, DEFB132, and C9orf92. Each is linked with SEMA3F in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA3F-to-partner and partner-to-SEMA3F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC185 grouped by SEMA3F-low versus SEMA3F-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3F→partner) and Y-score (partner→SEMA3F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCDC185 →	+0.048	+4.635	<.001	.003	3	1
SOFT_TISSUE	DEFB132 →	+0.009	+4.369	.003	.008	3	1
SOFT_TISSUE	C9orf92 →	+0.144	+4.369	<.001	.008	3	1
LUNG_NSCLC_LUAD	SCGB1C1 →	+0.055	+4.662	<.001	.005	3	1
SKIN	P2RY13 →	+0.005	+3.514	<.001	.001	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

CCDC185 by SEMA3F expression — SOFT_TISSUE

Explore this box plot interactively →