SEMA3E

Across TCGA patient cohorts, SEMA3E protein abundance is significantly associated with the RNA expression of many other genes, with 1,470 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SEMA3E-associated genes across cancer lineages are PLCB1, PLCB1-IT1, and MTMR8. Each is linked with SEMA3E in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA3E-to-partner and partner-to-SEMA3E results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEMA3E versus PLCB1 in LUAD, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA3E→partner) and Y-score (partner→SEMA3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLCB1 →	+1.375	+0.783	<.001	.003	3	2
LUAD	PLCB1-IT1 →	+1.571	+0.844	<.001	.001	3	2
UCEC	MTMR8 →	+1.224	+0.864	.001	<.001	3	1
LUAD	KLF8 →	-1.361	-1.102	<.001	.002	2	2
UCEC	OLFM4 →	+3.244	+0.945	.001	<.001	3	1
UCEC	HOXA1 →	-0.690	-0.827	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,470 associations by consensus.

SEMA3E vs PLCB1 — LUAD

Explore this scatter interactively →