SEMA3E

Across TCGA pan-cancer cohorts, SEMA3E RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SEMA3E data layer compared with 7 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher SEMA3E RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEMA3E expression acts as an unfavorable survival marker, although some lineages such as UCS and THCA show a favorable association.

UVM, KIRC, and LGG are the cancer types where SEMA3E RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.568	0.897	<.001	108	view →
KIRC	OS	Median	All	0.535	0.721	<.001	76	view →
LGG	OS	Median	All	0.738	0.879	<.001	36	view →
STAD	OS	Median	All	0.333	0.503	.011	35	view →
UCS	OS	Median	IV	0.732	0.224	.018	32	view →
THCA	DFS	Median	All	0.960	0.859	.005	21	view →
SCLC	DFS	Median	II,III,IV	0.594	0.316	.008	20	view →
PCPG	DFS	Median	All	0.973	0.871	.006	19	view →
BLCA	OS	Quartile	III,IV	0.283	0.529	.008	18	view →
ACC	OS	Quartile	All	0.715	0.900	.010	16	view →
OV	DFS	Quartile	IV	0.297	0.594	.003	12	view →
PRAD	DFS	Median	All	0.925	0.839	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SEMA3E–UVM (DFS)

Open the UVM breakdown →