SEMA3E

Across TCGA pan-cancer cohorts, SEMA3E RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SEMA3E’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SEMA3E RNA is repressed in tumor relative to normal tissue. In most cancer types SEMA3E is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and LUSC are the cancer types where SEMA3E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA3E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−2.746	<.001	11	view →
COAD	Male	II,III,IV	−1.487	<.001	11	view →
LUSC	Female	II,III,IV	−2.918	<.001	9	view →
HNSC	All	All	−0.413	.003	8	view →
READ	Female	All	−2.494	<.001	7	view →
LUAD	Female	All	−1.583	<.001	7	view →
KICH	Male	II,III,IV	−0.336	<.001	7	view →
KIRC	All	All	−0.283	<.001	5	view →
BRCA	Female	All	−0.831	<.001	4	view →
THCA	All	All	+0.564	<.001	3	view →
CHOL	All	All	+2.688	.002	2	view →
PRAD	All	All	−0.431	.049	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SEMA3E–BLCA

Open the BLCA breakdown →